Comparative in vitro evaluation of glimepiride containing nanosuspension drug delivery system developed by different techniques

The present study was aimed to develop the Glimepiride (GLM) loaded nanosuspension by different methods for increasing solubility of GLM. Twelve formulations were prepared combination method (FG), which included antisolvent precipitation followed sonication (Method 1) selecting drug and polymer in ratio 1:10, 1:20 1:30. Further 6 nanoprecipitation (Fg) 2) using polymers like polyvinyl pyrolidone (PVP K30), poly(ethylene glycol) (PEG) such as PEG 6000 400. GLM nanosuspensions techniques evaluated optical microscopy, percent entrapment efficiency (%EE), particle size analysis, zeta potential, transmission electron microscopy (TEM) vitro dissolution. FG1 formulation found be better showing 82.04% EE, 129–180 nm range, 30.16 mV 0.253 polydispersity index (PDI) 86.76% release compared Fgii having %EE, average size, PDI value 80.03%, 72–383 nm, -22.19 mV, 0.358 74.77%, respectively. On basis results obtained from studies, it can concluded that technique (FG) shows good dissolution than those (Fg), hence is a preferred prepare over technique.